Screening Adolescents for Type 2 Diabetes Mellitus in a Community Clinic
Sponsored by National Center for Research Resources (NCRR)
The purpose of this study is to evaluate the prevalence of Type 2 diabetes or impaired
glucose tolerance in a subset of children 10-19 years of age in an inner city community
clinic. The demographics of the clinic are 75% African American, 20% Hispanic, 5% other.
African American and Hispanic patients have a higher prevalence of diabetes with significant
morbidity, predominantly from microvascular and macrovascular disease. Obesity is commonly
seen in patients with Type 2 diabetes and contributes to the underlying insulin resistance
seen in the disease. Obesity is an increasing health problem among adolescents. Since Type
2 diabetes can be present for several years before diagnosis, it is worrisome that younger
children will have undiagnosed Type 2 diabetes for years. This will increase the risk of
earlier complications in these patients as young adults.
We hypothesize that the occurrence of abnormal glucose metabolism in 400 children with
either a history of obesity, family history of diabetes mellitus, or symptoms suggestive of
diabetes mellitus will be higher than the general pediatric population. We believe that a
family based educational program can reduce fasting plasma glucose.
Study Start Date: Not specified
Estimated Completion Date: Not specified
Internal Medicine: Endocrinology Endocrinology: Diabetes Nurse Practitioner: Community Health,Education/Training,Preventive Medicine
Behavioral: Family based educational program
Inclusion criteria for screening will be patients who have one of the following:
120% of ideal body weight or BMI> 27
Weight greater than 75th percentile
Family history of type 2 diabetes in first or second degree relative
Acanthosis nigricans or skin tags as signs of insulin resistance
Symptoms of hyperglycemia (polyuria, polydipsia, polyphagia, or recurrent infections)
Symptoms or signs of PCOS (hyperandrogenism, hirsutism, irregular menses)
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