Left atrial measures as predictors of heart failure in a low-risk population

Samar Mahmoud, MS | January 26, 2022

Previous studies have demonstrated that early changes to the left atrium and ventricle could serve as prognostic tools to predict future cardiac morbidity.


Study Design

This study included 1951 participants, without atrial fibrillation or significant valve disease, who underwent an echocardiographic examination between 2001 and 2003. 

The LAVImax and LAVImin were measured and the LA emptying fraction (LAEF) and LA expansion index (LAEI) were calculated for all patients. 

The primary endpoint of the study was defined as the time to a hospital contact due to incident HF, with the follow-up period extending until April 2018 or time of event.  

Results and Conclusions

During the follow-up period, 187 (10%) participants were diagnosed with HF.  Study participants diagnosed with HF had a larger LAVImin and LAVImax and a lower LAEF and LAEI compared to those not diagnosed with HF. 

After adjusting for multiple clinical and echocardiographic variables, only LAVImin was shown to be a predictor of incident HF, with a hazard ratio of 1.22 per 1 SD increase. The combination of LAVImin, LAEF, and LAEI provided useful prognostic information beyond an already established risk model for predicting HF. 

Related Research

Consider these findings from similar research studies:

  • The left atrial end-diastolic volume index (LAEDVI) is a strong predictor of cardiovascular events in patients with coronary heart disease (Source). 

  • Left atrial strain predictor of incident atrial fibrillation (Source)