UC affects an increasing number of patients worldwide. While the majority of patients have mild or moderate disease activity, 10-20% of patients have severe UC. Early detection of changes in disease activity are critical to guiding treatment plans and preventing complications.
The study consisted of 273 participants with UC. Outcomes of the study included: endoscopic activity; MH; and clinical remission. Clinical remission was defined as the absence of both high stool frequency (< 3 per day) and rectal bleeding. Subjects were divided into three CAR groups (low, moderate, and high).
Results and Conclusions
Investigators found a significant positive association between CAR and moderate to severe endoscopic activity. When investigators took into account the disease duration, high CAR was associated with moderate to severe endoscopic activity in the long-duration group (> 7 years), but not the short-duration group (≤ 7 years). Regardless of disease duration, CAR was not associated with clinical remission or MH.
Consider these findings from similar research studies:
CAR is a better predictor of patients with severe ulcerative colitis than C-reactive protein levels alone (Source).
CAR is predictive of infliximab failure and need for colectomy in patients with steroid-refractory acute severe ulcerative colitis (Source).