Multicenter prospective cohort study on current treatments of legg-calvé-perthes disease

Sponsored by Texas Scottish Rite Hospital for Children

Phase Quota
Phase N/A

Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0—14), but uncommon enough to have a sufficient number of patients from a single institution to perform a definitive prospective study comparing the results of current treatments. The present study will establish a database of prospectively identified patients with Legg-Calvé-Perthes (LCP) Disease and collect information regarding their presentation, treatment, and outcomes in the course of receiving currently available treatments. This study seeks to compare the outcomes of current treatments in the management of three age groups (ages 6—8, 8—11, >11) of patients with Perthes disease at two- and five-year followup. For each age group, two to three common treatment regimens currently used by practicing pediatric orthopaedic surgeons will be compared. The intervention a patient receives is determined through physician preference. Physicians pick an intervention for each age group and treat each patient with the same intervention.

Study Start Date: August 2012

Estimated Completion Date: September 2023

Specialties: Internal Medicine: Epidemiology Family Medicine: Epidemiology


  • Procedure: multiple epiphyseal drilling
  • Procedure: osteotomy

Inclusion criteria

  • Diagnosed with Legg-Calvé-Perthes disease
  • Between age 6-16
  • Patients with possible secondary femoral osteonecrosis if over the age of 11 due to trauma or corticosteroid therapy are also eligible

Exclusion criteria

  • Patients with previous surgical treatment

Study Locations And Contact Information

  • The University of Alabama at Birmingham, Birmingham Alabama
    Contact: Shawn Gilbert MD 205-975-7499
  • Phoenix Childrens Hospital, Phoenix Arizona
    Contact: Judson Karlen MD 602-546-1000
  • Kaiser Permanente Hospital, Los Angeles California
    Contact: Jeffrey Kessler MD 323-783-9313
  • Childrens Hospital of Los Angeles, Los Angeles California
    Contact: Paul Choi MD
  • Childrens Hospital Colorado, Aurora Colorado
    Contact: Eduardo Novais MD 720-777-6600
  • Connecticut Childrens Medical Center, Hartford Connecticut
    Contact: Philip Mack MD 660-545-8643
  • NemoursAlfred I duPont Hospital for Children, Wilmington Delaware
    Contact: Mihir Thacker MS DNB FCPS Ortho 302-651-4200
  • Childrens National Medical Center, Washington District of Columbia
    Contact: Benjamin Martin MD 202-476-4063
  • Childrens Orthopaedics of Atlanta, Atlanta Georgia
    Contact: Tim Schrader MD 678-686-6816
  • Lurie Childrens Hospital of Chicago, Chicago Illinois
    Contact: Joseph Janicki MD
  • Childrens Hospital Boston, Boston Massachusetts
    Contact: YoungJo Kim MD MS FRCSC 617-355-7497
  • Mayo Clinic, Rochester Minnesota
    Contact: Noelle Larson MD 507-284-2995
  • Gillette Childrens Specialty Healthcare, St. Paul Minnesota
    Contact: Jennifer Laine MD 651-578-5061
  • New York Presbyterian Hospital Columbia Campus, New York New York
    Contact: Joshua Hyman MD 212-305-5475
  • Montefiore Greene Medical Arts Pavilion, New York New York
    Contact: Eric Fornari MD 718-920-2060
  • OrthoCarolina, Charlotte North Carolina
    Contact: Virginia Casey MD 704-323-2543
  • Cincinnati Childrens Hospital Medical Center, Cincinnati Ohio
    Contact: Charles Mehlman DO MPH 513-636-4087
  • Nationwide Childrens Hospital, Columbus Ohio
    Contact: Kevin Klingele MD 614-722-3390
  • Childrens Hospital of Philadelphia, Philadelphia Pennsylvania
    Contact: Wudbhav Sankar MD 215-590-1527
  • University of TennesseeCampbell Clinic, Germantown Tennessee
    Contact: Derek M Kelly MD 901-759-5552
  • Texas Scottish Rite Hospital for Children, Dallas Texas
    Contact: Amanda Moualeu MPH 214-559-8543
  • Texas Childrens Hospital, Houston Texas
    Contact: Scott Rosenfeld MD 832-822-3109
  • Seattle Childrens Hospital, Seattle Washington
    Contact: Klane White MD MSC 206-987-5678
  • Universidade de So Paulo, São Paulo
    Contact: Roberto Guarniero MSc PhD FSBOT
  • University of Calgary, Calgary Alberta
    Contact: Fbio FerrideBarros MD FSBOT
  • The Hospital for Sick Children, Toronto Ontario
    Contact: Andrew Howard MD FRCSC 416-813-6430
  • Childrens Hospital HamburgAltona, Hamburg
    Contact: Ralf Stuecker MD 040 88908382
  • Kinderzentrum Mecklenburg, Schwerin
    Contact: Ludwig Meiss MD
  • Kasturba Medical College KMC Manipal, Manipal Karnataka
    Contact: Hitesh Shah 0820- 2922754
  • Seoul National University Childrens Hospital, Seoul
    Contact: WonJoon Yoo MD
  • Shriners Hospital for Children, Mexico City Mexico, DF
    Contact: Pablo Castaeda MD 5255 16647064
  • Oslo University Hospital, Oslo
    Contact: Ola Wiig MD PhD +4795168380
  • Medical University of Lodz Poland, Lodz
    Contact: Marek Synder MD
  • Bristol Royal Hospital for Children, Bristol Avon
    Contact: Simon Thomas 0117 3428755
  • University Hospital Southampton, Southampton
    Contact: Nicholas Clarke
  • Sanjeev Madan, Sheffield South Yorkshire
  • Johns Hopkins, Baltimore Maryland
  • BC Childrens Hospital, Vancouver British Columbia
  • NYU Hospital for Joint Diseases, New York City New York
  • Shriners Hospital for Children Salt Lake City, Salt Lake City Utah
  • IWK Health Centre, Halifax Nova Scotia

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