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Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)

Sponsored by National Institutes of Health Clinical Center (CC)

Phase Quota
Phase N/A

Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in childhood, affecting 3-5% of children between the ages of 7 and 17. Family studies suggest that there is a genetic component to ADHD. Scientists believe that it is a complex disorder in which two or more genes may be involved. Potentially eligible families will be asked to give written consent to participate and will be asked to complete questionnaires for each member in the family. In addition, an interview will be administered to the parent of minors enrolled in the study to determine their eligibility for being in the study. This screening tool is computerized and will take approximately 45 minutes to administer per child. Once screenings are completed, a blood collection kit will be sent to the family to take to their local medical care provider, have blood samples drawn and sent to NIH. There is no cost to the family to participate. We would like to enroll entire families, with both parents and all children.

Study Start Date: February 2000

Estimated Completion Date: Not specified

Specialties: Psychiatry: Child/Adolescent Psych,Mood Disorders Neurology: Neuropsych Sciences,Peds Neurology Pediatrics: Child/Adolescent Psych

Interventions

No interventions cited

Inclusion criteria

  • For both the U.S. and the Columbian Studies, we plan to obtain blood samples from subjects meeting the following criteria:
  • Children, ages 7-17, affected with ADHD with siblings who are either affected or unaffected, and their parents. (in the Columbian Study, we will also gather information and blood samples from extended families)
  • Adult participants 18 years or older selected for MRS from the Paisa population will be included if they:
  • share the haplotype that is in linkage disequilibrium at chromosome 11 p
  • do not have devices such as pace makers, cochlear implants, metal clips in the brain, etc that would preclude them from undergoing magnetic resonance technology
  • are not pregnant (pregnancy test will be administered) or breastfeeding
  • do not have a mental condition such as claustrophobia which would make magnetic resonance technology unacceptable to them
  • In both arms of the study, both male and female probands will be accepted of any ethnic background as long as they meet the criteria listed above. While there is a preponderance of males with ADHD, all clinics see both male and female research participants. Also, in most cases the family unit will involve the mother as well as the father for testing. Hispanic families will be specially enrolled in the Colombian arm
  • For the H MRS study, no one is excluded based on race, gender, or socioeconomic status
  • However, participants must meet the inclusion criteria described

Exclusion criteria

  • Exclude the following (if the condition could cause false positive ADHD):
    • Prematurity
    • Neurological conditions
    • Cardiac surgery
    • Prenatal drug exposure
    • Hydrocephaly
    • Mental Retardation (IQ< 80)
    • Known genetic syndromes
    • Known CNS disorders
    • Known lead toxicity
    • Tourette Disorder
    • Obsessive-Compulsive Disorder
    • Major Depression on both proband and affected sibling
    • Pervasive Developmental Disorder
    • Age under 7 years old
    • Autism
    • Other Psychoses
    • Post Traumatic Stress Disorder
    • Language Disorder (if known)
    • Severe Sensory Impairment (visual and hearing)
    • No bilineal families for statistical reasons are to be included, i.e. families in which both father and mother are known to be affected with ADHD. In order to involve either parent, there must be affected siblings
    • Include, but note:
    • Oppositional Defiant Disorder
    • Conduct Disorder
    • Tic Disorder
    • Obsessive/Compulsive Symptoms
    • Anxiety/Phobias
    • Learning Disabilities

Study Locations And Contact Information

  • University of California Irvine Medical Center, Orange California
  • National Institutes of Health Clinical Center 9000 Rockville Pike, Bethesda Maryland
  • National Institutes of Health Clinical Center 9000 Rockville Pike, Bethesda Maryland
  • University of California Irvine Medical Center, Orange California

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