Different value of HDL-C in predicting outcome of ARDS secondary to bacterial and viral pneumonia: A retrospective observational study

Heart & Lung; The Journal of Acute and Critical CareYang L, Luo Z, Shi X, et al. | October 15, 2020

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Researchers undertook this retrospective observational analysis to assess the prognostic worth of high density lipoprotein-cholesterol (HDL-C) concentrations in ARDS (acute respiratory distress syndrome) patients secondary to bacterial and viral pneumonia. Overall 108 pneumonia-ARDS patients in respiratory intensive care unit from 2017 to 2019 were analyzed. Two groups of participants were defined: bacterial ARDS group (56) and viral ARDS group (52). Bacterial ARDS patients vs viral ARDS patients were found to have statistically lower HDL-C levels. In receiver operating characteristic analysis, a superior prediction value for 28-day mortality was shown by HDL-C and also HDL-C < 0.42 mmol/L was identified to be significantly related to adverse results in bacterial ARDS patients. An independent risk for death of bacterial ARDS patients was shown to be conferred by low HDL-C. Based on these findings, experts concluded the likely worth of HDL-C as a marker to evaluate the 28-d mortality for bacterial ARDS patients rather than viral ARDS patients.

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