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Measurement of tryptase and CC16/albumin in nasal lavage fluid as a screening tool of allergic rhinitis

American Journal of Rhinology & AllergyKwon OE, Lee YC, Park JM, et al. | March 03, 2021

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In this investigation involving 45 patients with allergic rhinitis (AR) and 28 non-AR individuals, researchers sought to identify biomarkers in nasal discharge that may be used in biosensors to diagnose AR as an additional diagnostic tool. They chose the following five biomarkers in nasal fluids that represent the characteristics of allergic reactions based on previous research: tryptase, eosinophil cationic protein (ECP), interleukin 5 (IL-5), Clara cell protein 16 (CC16) and CC16-to-albumin ratio. Patients displayed rhinorrhea and tested positive on allergic skin and specific immunoglobulin E (IgE) tests were involved in the AR group, whereas the non-AR group involved people with no dominant nasal symptoms and tested negative on allergy tests. Findings suggested that the combination of “tryptase or CC16-to-albumin” could be used as an AR screening tool. While this diagnostic method cannot replace conventional diagnostic methods, it may be used as a secondary screening tool for patients who are unable to undergo allergy testing.

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