Atopic dermatitis: disease characteristics and comorbidities in smoking and non-smoking patients from the TREATgermany registry

Journal of the European Academy of Dermatology and VenereologyPilz AC, Schielein MC, Schuster B, et al. | December 02, 2021


Analysis of German registry data for atopic dermatitis (AD) patients revealed a higher disease burden in patients who smoke, with a different distribution pattern of lesions in adult-onset AD.

  • A non-interventional clinical registry (TREATgermany) of patients with moderate to severe AD in Germany was used to analyze 921 patients, 908 (male: 58.7%) with a mean age of 41.9 ± 14.4 informed about their smoking status.

  • Smoking patients had higher lesions’ intensity of oozing/crusts and excoriations as well as patient global assessment scores of AD severity, vs non-smoking ones.

  • A lower number of weeks with well-controlled AD and more severe pruritus were noted in smokers vs non-smokers.

  • Smokers exhibited more elevated total IgE levels as well as a younger age at the initial diagnosis of bronchial asthma.

  • Post-adjustment for potential confounders, the elevated intensity of oozing/crusts, the decreased number of weeks with well-controlled AD and the greater pruritus continued to be different in smokers vs non-smokers.

  • A 2.5 times higher likelihood of involvement of the feet was observed in smoking patients with adult-onset AD.

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