Lower plasma concentrations of short-chain fatty acids in patients with ADHD

Journal of Psychiatric ResearchScott Cunningham MD PhD, et al. | September 29, 2022



Decreased SCFA production, as shown in the current study, is known to slow dopaminergic transmission, affect the stability of neural membranes, and increase neuroinflammatory processes.

The plasma SCFA levels were measured by liquid chromatography-mass spectrometry in 233 patients with ADHD and 36 healthy family members.

In adults with ADHD the levels of formic acid, acetic acid, propionic acid, and succinic acid were lower than adults without ADHD.

In children with ADHD the levels of formic acid, propionic acid, and isovaleric acid were lower than children without ADHD.