Correlation between body mass index and prostate volume in benign prostatic hyperplasia patients undergoing holmium enucleation of the prostate surgery

BMC UrologyBatai K, Phung M, Bell R, et al. | June 11, 2021

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This study was carried out to assess if there was a correlation between body mass index (BMI) and pre-operative prostate volume and whether expression of two genes, alpha-2-macroglobulin ( A2M ) and transforming growth factor beta 3 ( TGFB3 ), was associated with BMI, pre-operative prostate volume, and age at surgery. Researchers retrospectively examined medical records of patients who had undergone holmium enucleation of the prostate surgery for treatment of benign prostatic obstruction. They conducted linear regression analysis to evaluate the relationship between BMI and prostate volume adjusting for demographic characteristics and comorbidity. They used Spearman’s correlation to analyze if gene expression was correlated with BMI, prostate volume, and age at surgery. The study enrolled a total of 278 patients, including 62.9% European Americans (n = 175) and 27.7% Hispanic Americans (n = 77). There is a positive association between BMI and prostate volume. It was shown that expression of TGFB3 and A2M was correlated with BMI, prostate volume, and age at surgery.

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