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Glomerular hyperfiltration and cancer: A nationwide population-based study

Cancer Epidemiology, Biomarkers & PreventionKim Y, Lee S, Lee Y, et al. | July 24, 2020

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This study was undertaken to determine whether and how glomerular hyperfiltration is related to the development of cancer, the most common reason for mortality, in an Asian population. For this purpose, experts retrospectively evaluated the National Health Insurance Service database of Korea for individuals who underwent national health screenings from 2012 to 2013. Glomerular hyperfiltration was defined as the 95th percentile and higher following stratification by gender and age decile. Overall 1,953,123 examinations for patients with a median observation span of 4.4 years were included. Findings revealed a raised risk for cancer development in particular organs, such as the stomach, colorectum, and liver and intrahepatic organ, in correlation with glomerular hyperfiltration.

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