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Use of hydrochlorothiazide and risk of non‐melanoma skin cancer in Koreans: A retrospective cohort study using administrative healthcare data

Clinical and Experimental DermatologyKim JC, et al. | November 23, 2020

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Researchers undertook this retrospective cohort analysis to determine the association between use of hydrochlorothiazide (HCTZ; one of the antihypertensive agents) and risk of non‐melanoma skin cancer (NMSC) in Korean people. Participants were 62,243 persons treated with HCTZ with a cumulative dose of ≥ 2,500 mg and 62,243 1:1 age‐, gender‐ and income level‐matched unexposed persons. According to the findings, an elevated risk of NMSC in Koreans, especially the older age group, could be seen in relation to cumulative use of HCTZ (≥ 2500 mg). Therefore, experts inferred that HCTZ could confer a risk for the development of NMSC not only in Caucasians but also in Asians.

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