Association of bariatric surgery with cancer incidence in patients with obesity and diabetes: Long-term results from the Swedish Obese Subjects Study

Diabetes CareSjöholm K, Carlsson LMS, Svensson PA, et al. | November 24, 2021


In order to determine the effect of bariatric surgery on cancer risk in patients with obesity and diabetes, researchers herein examined the long-term incidence of cancer after bariatric surgery and usual care among these patients in the matched prospective Swedish Obese Subjects (SOS) study.

  • A total of 701 patients with obesity and type 2 diabetes were analyzed at baseline, 393 of whom underwent bariatric surgery and 308 who received conventional obesity treatment.

  • The patients were followed up for a median time of 21.3 years (interquartile range 17.6–24.8 years, maximum 30.7 years).

  • The incidence rate for first-time cancer was 9.1 per 1,000 person-years vs 14.1 per 1,000 person-years in patients with obesity and diabetes treated with bariatric surgery vs usual obesity care, respectively.

  • Outcomes suggest that in patients with obesity and diabetes, bariatric surgery is linked with prevention of cancer.

  • Reduced cancer risk was recorded in correlation with durable diabetes remission.

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