Risk of cardiovascular disease among women carrying BRCA mutations after risk- reducing bilateral salpingo-oophorectomy: A population-based study
Gynecologic Oncology — Abreu do Valle H, Kaur P, Kwon JS, et al. | July 02, 2021
This retrospective population-based study was conducted to assess cardiovascular disease (CVD) risk after risk reducing bilateral salpingo-oophorectomy (RRBSO) in females carrying BRCA mutations. CVD risk was compared among women with known BRCA mutations who had RRBSO prior to the age of 50 (n = 360) with two groups of age-matched females without known BRCA mutations: 1) those who had bilateral oophorectomy for benign conditions (n = 3600); and, 2) those with intact ovaries who underwent hysterectomy or salpingectomy (n = 3600). Findings indicate an opportunity for improved CVD prophylaxis in females with BRCA mutations following preventive oophorectomy. This population had a lower prevalence of predisposing conditions for CVD and lesser use of cardioprotective medications but still the rate of CVD in this group was not lower.
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