Reservoir-excess pressure parameters independently predict cardiovascular events in individuals with type 2 diabetes

HypertensionAizawa K, Casanova F, Gates PE, et al. | June 11, 2021

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In several populations, the parameters derived from reservoir-excess pressure analysis have prognostic utility. This study attempted to ascertain whether these parameters were correlated with type 2 diabetes (T2DM) and whether they would predict cardiovascular events in individuals with T2DM. Researchers examined 306 people with T2DM with cardiovascular disease ([cardiovascular disease (CVD]; DMCVD, 70.4±7.8 years), 348 people with T2DM but without CVD (diabetes mellitus, 67.7±8.4 years), and 178 people without T2DM or CVD (control group [CTRL], 67.2±8.9 years). Via radial artery tonometry, reservoir-excess pressure analysis–derived parameters, including reservoir pressure integral, peak reservoir pressure, excess pressure integral, systolic rate constant, and diastolic rate constant, were collected. The findings revealed that altered reservoir-excess pressure analysis–derived parameters are correlated with T2DM. The outcomes suggest that baseline values of reservoir pressure integral and diastolic rate constant independently predict cardiovascular events in individuals with T2DM, demonstrating the potential clinical utility of these parameters for risk stratification in T2DM.

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