Azithromycin or doxycycline for asymptomatic rectal chlamydia trachomatis

New England Journal of MedicineLau A, Kong FYS, Fairley CK, et al. | June 25, 2021

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Among homosexual men, rectal chlamydia is identified as a common bacterial sexually transmissible infection. Researchers conducted a double-blind trial at five sexual health clinics in Australia, randomizing 625 homosexual men who had asymptomatic rectal chlamydia to receive either doxycycline (100 mg twice daily for 7 days) or azithromycin (1-g single dose). Outcomes suggest superiority of a 7-day course of doxycycline vs single-dose azithromycin in the treatment of rectal chlamydia infection among these study participants.

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