Renal hemodynamics across the adult lifespan: Relevance of flow pulsatility to chronic kidney disease

Experimental GerontologyKosaki K, Tarumi T, Tanahashi K, et al. | June 24, 2021

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In this study, the relationships among age, renal flow pulsatility, and chronic kidney disease (CKD) biomarkers in non-CKD adults and CKD patients were explored. Researchers enrolled 415 non-CKD adults and 136 CKD patients aged between 22 and 83 years who had undergone the renal blood flow measurement using duplex ultrasonography. Renal flow pulsatility was assessed by calculating pulsatility index and resistive index. They evaluated CKD biomarkers such as urinary liver-type fatty acid-binding protein and serum fibroblast growth factor 23 from each participant. Applanation tonometry measured aortic hemodynamic parameters. This study’s findings demonstrate that advancing age is correlated with a progressive elevation of renal flow pulsatility which manifests during middle age and accelerates in later life. Furthermore, increased renal flow pulsatility is correlated with the presence of CKD in each age group and also with biomarker levels that reflect CKD progression.

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