Detection of cancers and advanced adenomas in asymptomatic participants in colorectal cancer screening: A cross-sectional study

BMJ OpenSchult AL, Botteri E, Hoff G, et al. | July 02, 2021

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Researchers conducted a cross-sectional study to determine the detection rates for colorectal cancer (CRC) and advanced adenomas in asymptomatic CRC screening participants and bowel symptoms in association with CRC and advanced adenoma. Among 42,554 men and women (aged 50–74 years) who participated in a randomized CRC screening trial, a sigmoidoscopy (and follow-up colonoscopy if positive sigmoidoscopy) was performed in 36,059 participants and colonoscopy was conducted in 6,495 participants after a positive faecal immunochemical test (FIT). Observations revealed increased likelihood of being diagnosed with CRC or advanced adenoma in presence of some bowel symptoms. Rectal bleeding was correlated with detection of CRC and advanced adenoma, while alteration in bowel habits only with CRC detection. However, the individuals with these findings were asymptomatic in majority. Based on finding, they emphasize encouraging asymptomatic individuals to participate in CRC screening.

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