Cytochrome 4Z1 expression is associated with poor prognosis in colon cancer patients

OncoTargets and TherapyAl-Saraireh YM, Alshammari FOFO, Youssef AMM, et al. | November 12, 2021


Because of the relatively poor prognosis of patients diagnosed with colon cancer, new therapies are required. Researchers herein investigated the possible value of CYP4Z1, a tumor-related enzyme expressed in many tumors, as a potential biomarker or target for novel anticancer therapies in patients diagnosed with colon cancer.

  • A large panel of colon tissue types, including normal, benign, primary and metastatic ones, was examined immunohistochemically for CYP4Z1 overexpression.

  • Benign, primary and metastatic colon tissues showed a high CYP4Z1 expression while normal tissues had a weak or lack of expression.

  • High histological grades and late stages of the disease had a significantly high rate of CYP4Z1 expression, where patients with metastasis in the lymph nodes had its expression was more evident.

  • Overall findings suggest an independent value of CYP4Z1 expression as a prognostic predictor of poor overall survival of colon cancer patients and indicate its relevance as target for novel anticancer therapy development.


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