A multicenter phase II trial evaluating the efficacy of bevacizumab plus mFOLFOX6 for R0 surgical resection in advanced colorectal liver metastases harboring mutant-type KRAS: NEXTO-mt trial

HPBWatanabe G, Mise Y, Oba M, et al. | February 10, 2022

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Via this multicenter phase II trial, researchers sought to ascertain the efficacy and safety of bevacizumab plus mFOLFOX6 for patients with advanced colorectal liver metastases (CRLMs) harboring mutant-type KRAS.

  • Researchers performed evaluation of surgical indication every 4 cycles of bevacizumab plus mFOLFOX6 among patients with advanced CRLMs (tumor number of ≥5 and/or technically unresectable) harboring mutant-type KRAS.

  • Among 29 registered patients from six centers, complete and partial responses were observed at the rates of 0% and 62.1%, respectively.

  • There were 19 and 1 patient who received R0 and R1 resections, respectively (R0 resection rate: 65.5%).

  • Overall findings suggest achievement of a high R0 resection rate for advanced CRLMs harboring mutant-type KRAS by using bevacizumab plus mFOLFOX6, resulting in favorable survival.

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