Human cytomegalovirus and risk of incident cardiovascular disease in UK Biobank
The Journal of Infectious Diseases — Hamilton EM, Allen NE, Mentzer AJ, et al. | July 20, 2021
In this study, the relationships between human cytomegalovirus (HCMV) and incident cardiovascular disease (CVD), ischemic heart disease (IHD), and stroke were explored. Researchers enrolled 8,531 women and men of predominantly white ethnic background, aged 40–69 without prevalent CVD from the population-based UK Biobank study recruited between 2006–2010 with HCMV antibody levels measured. They determined CVD via linkage to health administrative records collected up to 2020. They further used Multivariate Cox proportional-hazards models to ascertain the relationship between HCMV seropositivity and incident CVD, IHD, and stroke. No significant relationship was found between HCMV seropositivity and risk of CVD, IHD or stroke. There is a need for future study within understudied populations, such as those of non-white ethnicity, and other CVD subtypes.