Long-term outcome following electroconvulsive therapy for late-life depression

The American Journal of Geriatric PsychiatryScott Cunningham MD PhD, et al. | June 29, 2022



The overall long-term response to treatment for LLD is poor; thus, devising alternative novel treatment options targeting the frontolimbic abnormalities and executive dysfunction networks in patients with LLD are warranted.

Data were obtained from the Mood Disorders in Elderly Treated with ECT (MODECT) study, which involved patients > 55 years of age (n=110; mean age=72.9 years) with a major depressive disorder (MDD). The primary outcomes were clinical course, cognitive impairment, and mortality 5 years following the initial treatment with ECT.

Of the patients who responded to the initial treatment with ECT, 67.1% relapsed, 38.8% had cognitive impairment, and 27.5% died.