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Association of granuloma annulare with type 2 diabetes, hyperlipidemia, autoimmune disorders, and hematologic malignant neoplasms

JAMABarbieri JS, Rosenbach M, Rodriguez O, et al. | June 11, 2021

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Utilizing a large population-based cohort study, experts aspired to explore whether there is a correlation between granuloma annulare (GA) and type 2 diabetes, hyperlipidemia, autoimmune conditions, and hematologic malignant neoplasms. In total, 5,137 patients with GA (3,760 women [73.2%]; mean [SD] age, 57.7 [19.0] years) were matched by age and gender with up to 10 randomly selected controls (n = 51,169; 37,456 women [73.2%]; mean [SD] age, 57.7 [19.0] years) with a diagnosis of a nevus or seborrheic keratosis. Individuals with GA were more likely to have baseline diabetes and hyperlipidemia, as well as baseline hypothyroidism and incident hypothyroidism than those without GA. No association was found between GA and an increased risk of hematologic malignant neoplasms. This study's findings indicate that diabetes and hyperlipidemia may be risk factors for the development of GA and that autoimmunity may play a role in the pathogenesis of GA.

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