Combined intralesional injection of tuberculin purified protein derivative (PPD) plus cryotherapy vs each alone in the treatment of multiple common warts

Dermatologic TherapyIbrahim H, El Taieb M, Nada E, et al. | February 03, 2022

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Findings demonstrate cryotherapy combined with intralesional injection of PPD and intralesional injection of PPD alone as better treatment options for multiple common warts, when compared with cryotherapy alone. However, better response could be achieved in combination of both cryotherapy and intralesional PPD with fewer number of sessions.

  • In this randomized clinical trial, patients with common warts were randomly split into three categories; group (A) comprised 25 patients subjected to cryotherapy, group (B) had 25 patients subjected to intralesional injection of tuberculin PPD and group (C) included 25 patients subjected to cryotherapy plus intralesional injection of tuberculin PPD.

  • A significant clinical improvement was achieved in all the three groups, with statistically significant difference between cryotherapy group (A) and intralesional injection of tuberculin PPD group (B) & between cryotherapy group (A) and cryotherapy plus intralesional injection of tuberculin PPD group (C).

  • However, no statistically significant difference was found between both intralesional injection of tuberculin PPD group alone (B) and cryotherapy plus intralesional injection of tuberculin PPD group (C).

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