Risk factors for COVID-19 hospitalization and death in people living with diabetes: A virtual cohort study from the Western Cape Province, South Africa

Diabetes Research and Clinical PracticeDave JA, Tamuhla T, Tiffin N, et al. | June 22, 2021

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Researchers sought to report on COVID-19 outcomes and risk factors, including comorbidities and medication regimens, in people living with diabetes (PLWD) for low- and middle-income countries. From the Provincial Health Data Center (Western Cape, South Africa), which is a health information exchange collating patient-level routine health data for nearly 4 million public sector healthcare seekers, they retrieved data of 64,476 COVID-19 patients. Of these, 9,305 were PLWD, 44.9% of whom were hospitalized, 4.0% admitted to ICU, 0.6% received ventilation and 15.4% died. Outcomes revealed significantly greater risk for hospital admission and mortality among PLWD. HIV infection, chronic kidney disease, current TB, male gender and increasing age were significant hospitalization risk factors. CKD, male gender, HIV infection, previous TB and increasing age were significant risk factors for mortality. A significantly increased risk for hospitalization and mortality was observed in correlation with pre-infection use of insulin and a reduced risk for hospitalization and mortality was recorded in correlation with using metformin.

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