Concomitant peripheral neuropathy and type 2 diabetes impairs post-exercise cutaneous perfusion and flowmotion

Journal of Clinical Endocrinology and MetabolismReynès C, Beaume JB, Latil-Plat F, et al. | June 11, 2021

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Researchers conducted the study for examining changes in microvascular perfusion during post-exercise recovery in those with type 2 diabetes, with or without peripheral neuropathy, as well as in healthy controls and those with obesity. Before and immediately after a six-minute walking test, each group's skin blood perfusion was measured using laser doppler flowmetry and laser speckle contrast imaging. After exercise, skin blood perfusion increased in all groups. Total spectral power increased in all groups after exercise. In those with confirmed peripheral neuropathy, the relative contributions of each endothelial band were lower than in healthy controls and those with obesity. When compared with those with subclinical peripheral neuropathy and obesity, those with confirmed peripheral neuropathy and type 2 diabetes alone had a lower neurogenic contribution.

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