Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study
Diabetes, Obesity and Metabolism — Birkeland KI, Bodegard J, Eriksson JW, et al. | May 05, 2020
Among T2D patients initially free from cardiovascular‐ and renal disease (CVRD), this inquiry was performed to determine the manifestation of CVRD as well as to investigate the associated mortality risks with these diseases. The participants were selected by analyzing health care records from England, Germany, Japan, the Netherlands, Norway and Sweden at a fixed date. First diagnose of cardiorenal disease, stroke, myocardial infarction (MI) or peripheral artery disease (PAD) event, defined CVRD manifestation. Relative to the CVRD‐free group, death risk related to single CVRD history of heart failure (HF), chronic kidney disease (CKD), MI, stroke or PAD was assessed. This large multinational study involved > 750,000 CVRD‐free T2D patients. In this study, the most frequent first CVD manifestations, consistently seen, were HF and CKD, and these were shown to be related to increased mortality risks, and thus these cardiorenal diseases appear crucial and serious complication for which enhanced preventive strategies are required.