A systematic review and meta‐analysis of interventions to preserve insulin‐secreting beta cell function in people newly diagnosed with type 1 diabetes: Results from intervention studies aimed at improving glucose control
Diabetic Medicine — Narendran P, Tomlinson C, Beese S, et al. | October 25, 2021
At diagnosis of type 1 diabetes, significant levels of beta cells remain. Improvement in glucose control and protection from long-term complications could be attained via preserving these cells. In this work, randomized controlled trials (RCTs) of interventions to preserve beta cell function in people newly diagnosed with type 1 diabetes are systematically reviewed and meta-analyzed.
This is the largest comprehensive review of RCTs in this area.
Researchers identified 28 studies with 1,662 participants and grouped them into six subgroups (alternative insulins, subcutaneous and intravenous insulin delivery, intensive therapy, glucose sensing, adjuncts) by intervention.
An improvement in glucose control as well as beta cell function was demonstrated in only three studies.
Intensive insulin therapy and use of an alternative insulin were the included interventions.
There was lack of robust evidence suggesting that in new onset type 1 diabetes, interventions to improve glucose control preserve beta cell function.
Read the full article on Diabetic Medicine