In a subset (n = 639) of the Reasons for Geographic and Racial Differences in Stroke Study (REGARDS) cohort, researchers constructed new, inflammation biomarker panel-weighted, dietary (DIS) and lifestyle (LIS) inflammation scores to better reflect dietary/lifestyle contributions to inflammation. They found statistically significant 1.66-, 4.29-, 1.56-, and 1.32-fold higher odds of an elevated high-sensitivity C-reactive protein (hsCRP) level (> 3 mg/dL) in those in the highest vs the lowest DIS, LIS, dietary inflammatory index, and empirical dietary inflammatory pattern quintiles, respectively. The odds of an elevated hsCRP level were statistically significantly 7.26-fold higher in those in the highest vs the lowest joint DIS/LIS quintile. The other two validation populations also showed similar findings. A substantial collective contribution of dietary and lifestyle exposures to systemic inflammation was supported in this study, as well as the use of the novel DIS and LIS.