Correlation of metabolic factors with endometrial atypical hyperplasia and endometrial cancer: development and assessment of a new predictive nomogram
Cancer Management and Research — Zhang H, Kong W, Han C, et al. | October 20, 2021
Metabolic factors associated with endometrial atypical hyperplasia and endometrial cancer are investigated, and a nomogram model to predict the risk of developing endometrial cancer was constructed.
Researchers obtained data of patients with endometrial atypical hyperplasia and endometrial cancer and included them as the case group.
Using the age-matched method, the control group was formed including patients with simple hyperplasia or polypoid hyperplasia of the endometrium during the same period.
A significant correlation appeared between the development of endometrial malignant hyperplasia and metabolic factors; the main risk factors were BMI > 25, hyperuricemia, and hyperlipidemia.
In addition, an association of hypertension, hyperglycemia and elevated CA199 was observed with the development of endometrial malignant hyperplasia.
Based on physical examination and laboratory testing, a nomogram prediction model was developed that can be employed as a rapid method for prediction of the risk of endometrial malignancy development and screening for risk factors in a population of women with metabolism-related high-risk factors.