Long-term survival outcomes and adverse effects of nasopharyngeal carcinoma patients treated with IMRT in a non-endemic region: A population-based retrospective study
BMJ Open — Xu M, Zang J, Luo S, et al. | August 03, 2021
Based on a large cohort (n = 792) and a long follow-up time (46.2 months), researchers discovered that the survival outcomes of nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy (IMRT) in China's non-endemic region are comparable to those in endemic regions. The most common acute and late toxicities observed in patients treated in endemic regions were similar.
The 5-year rates of local recurrence-free survival, regional recurrence-free survival, distant metastasis-free survival, disease-free survival (DFS) and overall survival (OS) in this population-based retrospective study were 90.8%, 97.0%, 82.8%, 69.6% and 78.0%, respectively, with a median follow-up time of 46.2 months.
Age, N stage, clinical stage, pathological type and primary tumor volume of greater than 23 cm 3 were found to be independent prognostic factors for DFS, whereas age, N stage, pathological type, cervical lymph node necrosis, and anemia were found to be significantly associated with OS.
Dermatitis, mucositis, and dysphagia were the most common acute IMRT toxicities.
The top two late toxicities were xerostomia and hearing impairment.
Distant metastasis and local and/or regional relapses were the most common failure patterns.
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