Diagnosis of chronic hepatitis B pericomplication: risk factors and trends over time

HepatologyLapointe-Shaw L, Chung H, Holder L, et al. | June 17, 2021

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This study was undertaken to investigate the proportion of chronic hepatitis B virus (HBV) diagnoses that are made within 6 months of presentation with a liver disease–related complication and examine associated factors and trends over time. Provincial laboratory data were used to distinguish individuals with chronic HBV diagnosed from 2003 to 2014. Researchers assessed the proportion who experienced a liver disease complication (decompensated cirrhosis, hepatocellular carcinoma, or liver transplant) within ±6 months of their HBV diagnosis date. Factors associated with HBV diagnosis pericomplication were ascertained by using multivariable logistic regression models. As per the findings, 1,279 (6.9%) developed an HBV-related complication during the follow-up period among 18,434 patients with chronic HBV. The findings revealed that a high proportion of individuals with HBV-related complications are first diagnosed with HBV pericomplication. According to the results, these signals missed opportunities for earlier detection and treatment. The data support expansion of HBV screening.

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