Hepatitis D‐associated hospitalizations in the United States: 2010‐2018

Journal of Viral HepatitisWasuwanich P, Striley CW, Kamili S, et al. | January 26, 2022


Hepatitis D-related hospitalizations were relatively uncommon in the U.S. but they were found to be linked with severe complications.

  • Using hospitalization data from the 2010-2018 National Inpatient Sample from the Healthcare Cost and Utilization Project, researchers identified 3,825 hepatitis D-associated hospitalizations.

  • Hepatitis D-associated hospitalization rate was between 6.9 to 20.7 per 10,000,000 but did not alter significantly over time.

  • Relative to hepatitis B only (HBV only), the hepatitis D cohort was found to have a greater proportion of males, Hispanics, hospitalizations in the Northeast region.

  • In hepatitis D-associated hospitalizations, there were significantly greater frequencies of liver failure, non-alcoholic cirrhosis, portal hypertension, ascites, and thrombocytopenia.

  • While similar mortality was noted in hepatitis D vs HBV only, the factors that elevated the odds of mortality within the hepatitis D cohort were: age >65 years (OR=3.79) and having a diagnosis of alcoholic cirrhosis (OR=3.37).

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