Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma

BMC GastroenterologyCai X, Deng J, Zhou J, et al. | October 19, 2021


In hepatocellular cancer (HCC), cyclin-dependent kinase 19 (CDK19) may serve as a prognostic marker but further exploration of its therapeutic potential is required.

  • The potential roles of CDK19 in HCC were investigated by using public databases and wet-bench hepatic cell line experiments.

  • HCC tissues, vs normal liver tissues, exhibited marked CDK19 upregulation, and a high diagnostic value of CDK19 mRNA expression was evident in HCC patients.

  • In cases with stage 2–3, stage 3–4, and grade 2 disease, CDK19 upregulation holds significant prognostic value for overall survival.

  • Eight of the 10 genes with correlation to CDK19 were found to have excellent prognostic value in HCC.

  • Direct involvement of these hub genes in cell division and regulation of the G2/M cell cycle transition was seen.

  • A high probability of the involvement of CDK19 in several cellular functions, such as proliferation, migration, and invasion is suggested by protein–protein interaction and pathway predictions.

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