Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: Single-institution 20-year study
BMC Gastroenterology — Nagaoki Y, Hyogo H, Ando Y, et al. | August 03, 2021
Among patients with hepatocellular carcinoma (HCC), 23.6% had an occurrence of nonhepatitis B and nonhepatitis C viral (NBNC)-HCC.
A rapid increase in the prevalence of NBNC-HCC has occurred.
NBNC-HCC increased from 26.5% in 2009 to 46.3% in 2018.
Significantly old age, and significantly higher rates of excessive alcohol consumption, T2DM, hypertension, and hyperlipidemia characterize patients with NBNC-HCC.
The BMI and platelet count were significantly higher and the FIB-4 index was significantly lower in patients with NBNC-HCC.
An important risk factor for HCC was metabolic syndrome.
Patients with non-cirrhotic livers also had an occurrence of HCC.
The FIB-4 index is possibly a valuable screening tool for HCC in patients with NBNC.
Read the full article on BMC Gastroenterology