Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: Single-institution 20-year study

BMC GastroenterologyNagaoki Y, Hyogo H, Ando Y, et al. | August 03, 2021


Among patients with hepatocellular carcinoma (HCC), 23.6% had an occurrence of nonhepatitis B and nonhepatitis C viral (NBNC)-HCC.

  • A rapid increase in the prevalence of NBNC-HCC has occurred.

  • NBNC-HCC increased from 26.5% in 2009 to 46.3% in 2018.

  • Significantly old age, and significantly higher rates of excessive alcohol consumption, T2DM, hypertension, and hyperlipidemia characterize patients with NBNC-HCC.

  • The BMI and platelet count were significantly higher and the FIB-4 index was significantly lower in patients with NBNC-HCC.

  • An important risk factor for HCC was metabolic syndrome.

  • Patients with non-cirrhotic livers also had an occurrence of HCC.

  • The FIB-4 index is possibly a valuable screening tool for HCC in patients with NBNC.

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