Prevalence of high-risk human papillomavirus by RNA assay in home self-collected samples among underscreened people in North Carolina
Sexually Transmitted Diseases — Lee F, Bukowski A, Spees LP, et al. | February 08, 2022
The risk of being underscreened for cervical cancer is found to be highest for low-income and uninsured people with a cervix (PWC). Researchers investigated high-risk human papillomavirus (hrHPV) prevalence on home self-collected samples in this at-risk population and determined the rates of in-clinic follow-up and risk factors linked with hrHPV positivity.
My Body My Test 3 was carried out among individuals aged 25 to 64 years, overdue for cervical cancer screening, and with incomes of < 250% of the US Federal Poverty Level.
Participants randomized to the self-collection arm, who provided self-collected cervicovaginal brush samples for HPV testing (n = 329), formed the analytic sample.
Self-collected samples showed hrHPV RNA prevalence of 16% (n = 52/329).
Twenty-four of the hrHPV-positive participants (46%) vs 56 (20%) of hrHPV-negative participants presented for in-clinic cervical cancer screening.
Likelihood of being hrHPV positive appeared to be double for individuals with ≥ 2 sexual partners in the past year.
Attitudes toward screening were similar among high-risk HPV-positive and HPV-negative participants, with the exception of hrHPV-positive participants who described a lower perceived risk of cervical cancer than those who were hrHPV negative.
Overall there appeared similar hrHPV RNA prevalence to findings in other underscreened PWC in the United States.
Researchers emphasize making efforts to reach underscreened PWC for cervical cancer prevention.