Systemic inflammatory response syndrome is associated with increased mortality across the spectrum of shock severity in cardiac intensive care patients

Circulation: Cardiovascular Quality and OutcomesJentzer JC, Lawler PR, van Diepen S, et al. | December 08, 2020

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Researchers undertook this retrospective study to investigate the link of systemic inflammatory response syndrome (SIRS) with illness severity as well as survival across the spectrum of shock severity in cardiac intensive care unit (CICU) patients. A total of 8,995 unique patients admitted to the Mayo Clinic CICU between 2007 and 2015 were examined. The presence of SIRS was detected in 33.9% of patients on CICU admission and SIRS was identified to be more prevalent in advanced SCAI (Society for Cardiovascular Angiography and Interventions) shock stages. Following multivariable adjustment, SIRS was found to be related to higher hospital as well as 1-year death in patients in SCAI shock stages A through D but not SCAI shock stage E. Per findings, the clinical criteria for SIRS was met by one-third of CICU patients at the time of admission, and these patients experienced higher illness severity as well as worse results across the spectrum of SCAI shock stages. CICU patients carrying an elevated risk of short-term and long-term death were detected by the presence of SIRS.

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