Depletion of omega-3 fatty acids in RBCs and changes of inflammation markers in patients with morbid obesity undergoing gastric bypass
The Journal of Nutrition — Hajri T, Ewing D, Talishinskiy T, et al. | June 14, 2021
This study was undertaken to determine if Roux-en-Y-gastric bypass (RYGB) alters essential fatty acid (FA) status and inflammation markers. Obese participants (n = 28; BMI > 40 kg/m 2; mean age 48 years) were studied before and 1 year after RYGB. The authors obtained blood samples before and 12 months after RYGB, and analyzed FA in RBCs and peripheral blood mononuclear cells (PBMC), and measured inflammation parameters in plasma. This study shows that RBC and PBMC n-3 FAs are significantly reduced in obese patients after RYGB. DHA supplementation in PBMC moderates the production of inflammation markers, implying that n-3 FA supplementation in bariatric patients should be investigated.
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