Characteristics and serotype distribution of childhood cases of invasive pneumococcal disease following pneumococcal conjugate vaccination in England and Wales, 2006–2014

Authors here aim at assessing the risk, clinical characteristics, or outcomes of 13–valent pneumococcal conjugate vaccine (PCV13) compared to 7–valent pneumococcal conjugate vaccine (PCV7) failure. Observations reveal that PCV failure is rare and, compared to PCV7 serotypes, the additional PCV13 serotypes are more likely to cause bacteremic lower respiratory tract infection (LRTI) and empyema in healthy vaccinated children.