The incidence, risk factors and predictive nomograms for early death of lung cancer with synchronous brain metastasis: A retrospective study in the seer database

BMC CancerShen H, Deng G, Chen Q, et al. | July 19, 2021

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Researchers sought to report on the early mortality and related factors in patients with lung cancer with synchronous brain metastasis (LCBM). From the Surveillance, Epidemiology, and End Result (SEER) database, they enrolled a total of 29,902 patients with LCBM in this study. Among these, early death was reported for 13,275 (44.4%) patients, and death due to lung cancer was recorded in 11,425 (38.2%) cases. For overall and cancer-specific early death, the following were identified as significant independent risk factors: age, race, gender, Gleason grade, histological type, T stage, N stage, bone metastasis, liver metastasis and marital status. Incorporating these factors, a nomogram was constructed to predict early death in lung cancer patients with synchronous brain metastases. Using nomograms, better treatment strategies may be developed, such as clinical trials and hospice care.

Read the full article on BMC Cancer

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