Influenza vaccine and risk of acute myocardial infarction in a population- based case-control study

Heartde Abajo FJ, Rodríguez-Martín S, Barreira D, et al. | October 15, 2021


Correlation of influenza vaccination with risk of a first acute myocardial infarction (AMI) in the general population was examined by different epidemic periods.

  • A population-based case–control study of patients aged 40–99 years was carried out in BIFAP (Base de datos para la investigación farmacoepidemiológica en atención primaria), over 2001–2015.

  • Vaccinated individuals were those who received influenza vaccination at least 14 days prior to the index date within the same season.

  • Included were 24,155 AMI cases and 120,775 matched controls.

  • Shortly after vaccination, a reduction in the risk of AMI occurred and this protection persisted over time.

  • Researchers retrieved similar findings during the pre-epidemic, epidemic and postepidemic periods.

  • Overall influenza vaccine show a moderate protective effect against AMI in the general population, mostly in primary prevention,

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