Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment

NeuroImage: ClinicalKocher M, Jockwitz C, Caspers S, et al. | June 26, 2020

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This study was undertaken to evaluate the role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment. Researchers recruited a total of 80 patients (median age, 51 years) with glioma (WHO grade IV glioblastoma, n = 57; WHO grade III anaplastic astrocytoma, n = 13; WHO grade III anaplastic oligodendroglioma, n = 10) and ECOG performance score 0–1 who had undergone resting-state functional MRI (rs-fMRI) and neuropsychological testing at a median interval of 13 months (range, 1–114 months) after initiation of therapy. The data showed that for malignant glioma patients, personalized treatment strategies should consider the left parietal and temporal DMN nodes as vulnerable regions concerning the neurocognitive outcome.

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