Sleep apnea is associated with accelerated vascular aging: Results from 2 European community‐based cohort studies

Journal of the American Heart AssociationLisan Q, van Sloten T, Boutouyrie P, et al. | July 28, 2021

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Researchers compared patients with high vs low risk of obstructive sleep apnea (OSA) in terms of the magnitude of vascular aging. They used 2 community‐based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study. They evaluated carotid artery properties, and carotid‐femoral pulse wave velocity (in the Maastricht Study only). This analysis involved 8615 participants without prior cardiovascular disease. In the PPS3 and Maastricht Study, high risk of OSA prevalence was estimated to be 16.8% (n=1150) and 23.8% (n=423), respectively. Post-adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site, a high risk of OSA was found to be related to greater carotid intima‐media thickness, Young’s elastic modulus, carotid‐femoral pulse wave velocity, carotid pulse wave velocity, and carotid diameter. Overall, findings revealed that individuals with high risk of OSA exhibited accelerated vascular aging. This may, at least partially, underlie the link between OSA and cardiovascular disease.

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