Association between obstructive sleep apnea and quantitative atherosclerotic plaque burden: A coronary computed tomographic angiography study

ChestLu M, Fang F, Wang Z, et al. | July 29, 2021

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Using cross-sectional data, researchers investigated if obstructive sleep apnea (OSA) severity-related indices are associated with the presence and burden of coronary plaque. Participants were 692 patients who underwent sleep monitoring and coronary computed tomographic angiography. Of these, 120 (17.3%) had polysomnography, and 572 (82.7%) had respiratory polygraphy. Multivariable analyses revealed more likelihood of having coronary plaques in patients suffering from moderate-severe OSA and it was more likely that plaques consist of noncalcified plaque (NCP) component and low-density NCP (LD NCP) component. A significantly higher total plaque volume, NCP volume and LD NCP volume were present in severe OSA cases vs no or mild OSA cases. Findings demonstrated an independent link of OSA with the presence as well as with burden of coronary plaque, thus, indicating an elevated risk of coronary events.

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