Effect of intra-articular platelet-rich plasma vs placebo on pain and cartilage volume in knee osteoarthritis

JAMABennell KL, Paterson KL, Metcalf BR, et al. | November 29, 2021


In this study, treatment with platelet-rich plasma (PRP) for mild to moderate knee osteoarthritis (OA), compared with saline injection, did not significantly improve knee pain or slow disease progression. Overall, PRP use to treat knee OA is not supported.

  • This is a randomized clinical trial comprising 288 adults aged 50 years or older with mild to moderate radiographic knee OA.

  • PRP use as a treatment option, vs placebo injection, led to a mean change in knee pain scores of −2.1 vs −1.8 on an 11-point scale (range, 0-10) as well as a mean change in medial tibial cartilage volume of −1.4% vs −1.2% at 12 months.

  • Neither comparison was statistically significant.

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