In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1

Osteoporosis InternationalGoetz TG, Nair N, Shiau S, et al. | October 22, 2021

Advertisement

Marked deficits are observed in bone microarchitecture among premenopausal women with idiopathic osteoporosis (IOP) but with variable bone remodeling. In researchers’ previous work, those with low tissue-level bone formation rate (BFR) were demonstrated to exhibit less responsiveness to teriparatide and have higher serum IGF-1, a hormone anabolic for osteoblasts and other tissues. Herein, they examined if IOP women with low BFR have higher IGF-1 and paradoxical IGF-1 associations in skeletal and non-skeletal tissues, and if IGF-1 and the related measures are predictive of teriparatide response.

  • An ancillary study to a 24 month clinical trial of teriparatide for IOP.

  • Participants were premenopausal women with IOP (n = 34).

  • In line with observations in other populations, correlation of lower BFR with higher body fat and poorer teriparatide response was evident.

  • However, in contrast to other populations, higher IGF-1 was observed in correlation with low BFR, higher body fat, as well as with poorer teriparatide response: inverse correlation was evident between IGF-1 Z-score and BFR at all bone surfaces, whereas IGF-1 Z-score directly linked to central fat and leptin.

  • Inverse correlation of IGF-1 was observed with 24 month hip BMD % change.

  • Overall there were paradoxical IGF-1 relationships suggesting a possible contribution of abnormal or atypical regulation of bone and fat to osteoporosis mechanisms in premenopausal IOP.

Read the full article on Osteoporosis International

Advertisement