Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: Implications for Fracture Risk Assessment Tool (FRAX)-derived estimates
Journal of Bone and Mineral Research — Chakhtoura M, Dagher H, Sharara S, et al. | August 03, 2021
According to this systematic review, the incidence rate ratio (IRR) of major osteoporotic fracture (MOF)/hip fracture may differ between countries. When country-specific fracture IRRs are not used, the variability at older ages may affect Fracture Risk Assessment Tool prediction.
This research focused on observational studies of MOF and hip fractures in people > 50 years.
With few exceptions, the IRRs were two to ten times higher in younger age groups compared with older age groups, and in women than in men.
Within Europe, and using Sweden as a reference, MOF/Hip IRRs in women aged 50–54 years from Finland, Italy, Netherlands, Denmark, and the United Kingdom were reduced by 38% to 60%.
The results were comparable in men.
MOF/Hip IRRs were consistently lower in women from European countries compared with Sweden at older ages, by 10%–40% and 11%–51%, at 75–79 years and 85–89 years, respectively.
Men's and non-European countries' findings were mixed.