Associations of body mass index-metabolic phenotypes with cognitive decline in Parkinson disease
European Neurology — Zhang L, Gu LY, Dai S, et al. | October 25, 2021
In Parkinson disease (PD), a rapid cognitive decline was observed in the presence of metabolically unhealthy normal weight (MUNW) phenotype.
This study involved 139 PD patients who had complete laboratory measurements, demographic and anthropometric parameters at baseline.
Patients were divided into 4 different BMI-metabolic status phenotypes based on Adult Treatment Panel-III criteria: (1) MUNW; (2) metabolically unhealthy obesity; (3) metabolically healthy normal weight; and (4) metabolically healthy obesity.
More cognitive decline in global cognition and visuospatial perception was found in PD patients in the MUNW group vs those in the other 3 groups.
Motor scales did not differ among different BMI-metabolic status phenotypes.
Lower CSF Aβ42 and serum neurofilament levels were found in the metabolically healthy obesity group vs the metabolically healthy normal weight group.
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