Plasma secretory phospholipase A2 as an early marker for late-onset sepsis in preterm infants-A pilot study

Acta PediatricaHibbert J, Armstrong NJ, Granland C, et al. | June 28, 2021

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Since there is an urgent need for more rapid, accurate adjunctive diagnostics in late-onset sepsis (LOS) to improve management and minimize antibiotic exposure in preterm infants, researchers sought to measure the diagnostic performance of secretory phospholipase A2 type IIA (sPLA2-IIA) in very preterm infants (< 30 weeks gestational age) with suspected LOS. When comparing infants with and without LOS, plasma sPLA2-IIA levels were found to be higher in those with LOS. This pilot study suggests that sPLA2-IIA may be clinically useful for the early detection of LOS in very preterm infants, potentially informing clinical management and antibiotic stewardship.

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