The impact of comorbidities and their stacking on short- and long-term prognosis of patients over 50 with community-acquired pneumonia

BMC Infectious DiseasesBlanc E, Chaize G, Fievez S, et al. | September 15, 2021


The outcomes of hospitalized patients with community-acquired pneumonia (CAP) and pneumococcal infection CAP (P-CAP) are possibly influenced by specific comorbidities as well as by the number of combined comorbidities and the combination of at-risk (AR) and high-risk (HR) comorbidities.

  • From the 2014 French Information Systems Medicalization Program (PMSI), data of 182,858 patients was retrieved.

  • Of these patients, 149,555 patients aged ≥ 50 years (nonagenarians 17.8%) were hospitalized for CAP, including 8,270 with P-CAP.

  • Overall, 33.8% had ≥ 1 HR comorbidity and 90.5% had ≥ 1 AR comorbidity.

  • The most frequent AR comorbidity was cardiac diseases (all CAP: 77.4%).

  • Transfer in ICU was required for 5.4% of CAP cases and 19.4% for P-CAP.

  • There appeared an increase in short-term and 1-year in-hospital mortality rates mostly with age, and with the number of comorbidities and combination of AR and HR comorbidities, in addition of specific comorbidities.

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